Regulation Due to Lack of CD22-Mediated Signal Containing IgE but not That Containing IgA Augmentation of Signaling through BCR
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چکیده
منابع مشابه
بررسی میزان سرمی ایمونوگلوبولین های IgG و IgM و IgA و IgE و شمارش لنفوسیت های (+B(CD22 در بیماران مبتلا به بیماری بهجت در ایران
The Behcet disease (BD) is a systemic inflammatory disease of unknown etiology. Evidences suggest that at least some of the clinical aspect of the BD may be due to autoimmune responses, these includes elevated levels of immunoglobulins (Igs) and immune complexes. To clarify the molecular basis of the changes in the level of different classes of Igs in BD, we have detected the amount of IgG, IgM...
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B cell antigen receptor (BCR) engagement can lead to many different physiologic outcomes. To achieve an appropriate response, the BCR signal is interpreted in the context of other stimuli and several additional receptors on the B cell surface participate in the modulation of the signal. Two members of the Siglec (sialic acid-binding immunoglobulin-like lectin) family, CD22 and Siglec-G have bee...
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C3dg is a cleavage product of the C3 component of complement that can facilitate the coligation of the complement receptor 2 (CR2/CD21) with the BCR via C3dg/Ag complexes. This interaction can greatly amplify BCR-mediated signaling events and acts to lower the threshold for B cell activation. Although previous studies have used anti-CR2 Abs or used chimeric Ags in the context of BCR transgenic ...
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CD22 is a B cell-restricted transmembrane protein that apparently controls signal transduction thresholds initiated through the B cell Ag receptor (BCR) in response to Ag. However, it is still poorly understood how the expression of CD22 is regulated in B cells after their activation. Here we show that the expression levels of CD22 in conventional B-2 cells are markedly down-regulated after cro...
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The immunoreceptor tyrosine-based inhibition motif (ITIM) is found in various membrane molecules such as CD22 and the low-affinity Fc receptor for IgG in B cells and the killer cell-inhibitory receptor and Ly-49 in NK cells. Upon tyrosine phosphorylation at the ITIMs, these molecules recruit SH2 domain-containing phosphatases such as SH2-containing tyrosine phosphatase-1 and negatively regulate...
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